Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. DNAJC6 Antibody

DNAJC6 Antibody

  • 货号：
    CSB-PA007040LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007040LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA007040LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA007040LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNAJC6 Polyclonal antibody
  • Uniprot No.：
    O75061
  • 基因名：
  • 别名：
    DNAJC6 antibody; KIAA0473 antibody; Putative tyrosine-protein phosphatase auxilin antibody; EC 3.1.3.48 antibody; DnaJ homolog subfamily C member 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Putative tyrosine-protein phosphatase auxilin protein (201-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DNAJC6 Antibody (CSB-PA007040LA01HU)，的标记方式是Non-conjugated。对于DNAJC6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007040LB01HU DNAJC6 Antibody, HRP conjugated ELISA
    FITC CSB-PA007040LC01HU DNAJC6 Antibody, FITC conjugated
    Biotin CSB-PA007040LD01HU DNAJC6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons.
  • 基因功能参考文献：
    1. DNAJC6 mutations are not common causes of early onset Parkinson's disease in Chinese population PMID: 27687717
    2. DNAJC6 mutations are associated with early-onset Parkinson's disease. PMID: 26528954
    3. DNAJC6 is up-regulated in hepatocellular carcinoma tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC PMID: 25446072
    4. Missense mutations in DNAJC6 does not play a major role in PD in the Chinese population. PMID: 24126164
    5. we did not detect any heterozygous or homozygous c.801-2A>G mutation in DNAJC6 in a cohort of Parkinson disease patients from southern Spain. PMID: 24220513
    6. This review presented that DNAJC6 in recessive forms of juvenile parkinsonism. PMID: 24262182
    7. Our findings further establish DNAJC6 as a juvenile parkinsonism gene, and expand the spectrums of the parkinsonism phenotype and DNAJC6 mutation PMID: 23211418
    8. study reports a homozygous mutation in DNAJC6 in two patients with autosomal-recessive juvenile Parkinsonism; the mutation was associated with abnormal transcripts and marked reduced DNAJC6 mRNA level PMID: 22563501
    9. The DNAJC6 gene encodes auxilin-1, a protein required for clathrin-dependent recycling of synaptic vesicles in neurons that is possibly at the origin of the mental retardation and epilepsy phenotype PMID: 22647716
    10. there are two auxilins with overlapping functions; they not only facilitate the uncoating of clathrin-coated vesicles but also prevent the formation of nonproductive clathrin cages in the cytosol PMID: 18489706

    显示更多

    收起更多

  • 相关疾病：
    Parkinson disease 19A, juvenile-onset (PARK19A); Parkinson disease 19B, early-onset (PARK19B)
  • 组织特异性：
    Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle a
  • 数据库链接：

    HGNC: 15469

    OMIM: 608375

    KEGG: hsa:9829

    STRING: 9606.ENSP00000378735

    UniGene: Hs.647643