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DNAJC7 Antibody

  • 货号：
    CSB-PA747689
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA747689(DNAJC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA747689(DNAJC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human seminoma tissue, Primary antibody: CSB-PA747689(DNAJC7 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q99615
  • 基因名：
    DNAJC7
  • 别名：
    DJ11 antibody; DJC7 antibody; DnaJ (Hsp40) homolog subfamily C member 7 antibody; DnaJ homolog subfamily C member 7 antibody; Dnajc7 antibody; DNJC7_HUMAN antibody; Tetratricopeptide repeat domain 2 antibody; Tetratricopeptide repeat protein 2 antibody; TPR repeat protein 2 antibody; TPR2 antibody; TTC2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DNAJC7
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.
  • 基因功能参考文献：
    1. The data from the current study for the first time demonstrated increased serum polyglutamylated DNAJC7 as a potential biomarker for renal cell carcinoma early detection PMID: 26993597
    2. ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers PMID: 24789201
    3. TPR2 exhibited strong interaction with glucocorticoid receptor and progesterone receptors. PMID: 20661446
    4. TPR2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. PMID: 12853476
    5. Data show that Tpr2 associates with Hsp90 and Hsp70 complexes, promoted the accumulation of Hsp70 in PR heterocomplexes in the presence of Hsp90. Thus, Tpr2 has the potential to regulate PR chaperoning. PMID: 18620420

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
  • 数据库链接：

    HGNC: 12392

    OMIM: 601964

    KEGG: hsa:7266

    STRING: 9606.ENSP00000406463

    UniGene: Hs.500156