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DNM3 Antibody

  • 货号：
    CSB-PA319466
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA319466(DNM3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQ16
  • 基因名：
  • 别名：
    testicular dynamin antibody; testicular antibody; DNM 3 antibody; DNM3 antibody; DNM3 protein antibody; Dyn3 antibody; DYN3_HUMAN antibody; Dyna III antibody; DynaIII antibody; dynamin 2 antibody; Dynamin antibody; Dynamin family member antibody; Dynamin testicular antibody; Dynamin-3 antibody; Dynamin3 antibody; EC 3.6.5.5 antibody; KIAA0820 antibody; MGC70433 antibody; T dynamin antibody; T-dynamin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human DNM3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
  • 基因功能参考文献：
    1. In glioma, elevated miR-221 expression is a biomarker for glioma. DNM3 is a target of miR-221 and RELA regulates miR-221 expression. PMID: 27837435
    2. Genetic variability in DNM3 modifies age of onset for LRRK2 Gly2019Ser parkinsonism. PMID: 27692902
    3. DNM3 may be involved in risk of obsessive-compulsive disorder. PMID: 27023174
    4. Microdeletion of DNM3 harboring miR199 and miR214 is associated with skeletal abnormalities. PMID: 26333682
    5. DNM3 attenuates the proliferation and induces apoptosis of gastric cancer cells. PMID: 26784388
    6. Data show that the classical dynamin DNM1 and DNM3 genes reach their maximum expression levels (100% of maximal expression) in all normal central nervous system tissues studied. PMID: 24673776
    7. Data indicate that dynamin 3 (DNM3) harbors MEIS1 binding sites and is associated with differences in mean platelet volume (MPV). PMID: 22972982
    8. DNM3 not only participates in megakaryocyte progenitor amplification, but is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. PMID: 21671749
    9. Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients. PMID: 20700106
    10. dynamin-3 and the postsynaptic adaptor Homer positions the endocytic zones near the postsynaptic density PMID: 17880892
    11. Upon comparison of PBMC and skin samples of Sezary syndrome versus mycosis fungoides, CDO1 and DNM3 were found upregulated only in Sezary syndrome. PMID: 18033314
    12. Dynamin 3 participates in the growth and development of megakaryocytes. PMID: 19007685

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 数据库链接：

    HGNC: 29125

    OMIM: 611445

    KEGG: hsa:26052

    STRING: 9606.ENSP00000350876

    UniGene: Hs.654775