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DNMBP Antibody

  • 货号：
    CSB-PA007081GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6XZF7
  • 基因名：
    DNMBP
  • 别名：
    Dnmbp antibody; DNMBP_HUMAN antibody; Dynamin binding protein antibody; Dynamin-binding protein antibody; KIAA1010 antibody; Scaffold protein Tuba antibody; TUBA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DNMBP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells. Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a role in ciliogenesis. May play a role in membrane trafficking between the cell surface and the Golgi.
  • 基因功能参考文献：
    1. The rs3740058 in DNMBP was significantly differently in genotype between Alaheimer diease and control in APOE epsilon4epsilon4 subgroup, but showed no effect on Alzheimer disease risk, either did rs11190305 polymorphisms in DNMBP. PMID: 25801238
    2. Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation PMID: 25422375
    3. Polyproline region of N-WASP is required for the localization of Tuba at the pre-apical patch. PMID: 21677511
    4. findings underscore a role for DNMBP in the genetic risk for late-onset Alzheimer's disease in the Belgian population PMID: 18359537
    5. functions to bring together dynamin with actin regulatory proteins PMID: 14506234
    6. Results confirmed DNMBP may be one of the susceptibility genes for Alzheimer's disease. PMID: 16740596
    7. Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors. PMID: 17015620
    8. We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs of Dynamin Binding Protein. PMID: 17442457
    9. Although DNMBP is an excellent candidate gene because of its role in the APP recycling pathways and being located within a chromosome 10 linkage region, we are unable to confirm that DNMBP is associated with LOAD PMID: 18452187

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction.
  • 组织特异性：
    Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 30373

    OMIM: 611282

    KEGG: hsa:23268

    STRING: 9606.ENSP00000315659

    UniGene: Hs.500771