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  4. DOK4 Antibody

DOK4 Antibody

  • 货号：
    CSB-PA002184
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse lung cells using Dok-4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8TEW6
  • 基因名：
    DOK4
  • 别名：
    DOK4Docking protein 4 antibody; Downstream of tyrosine kinase 4 antibody; Insulin receptor substrate 5 antibody; IRS-5 antibody; IRS5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Dok-4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
  • 基因功能参考文献：
    1. the current study have explored in more detail the structure and function of the Dok-4 PTB domain. PMID: 22982678
    2. DOK4 expression in human T cells has been demonstrated, and its genomic structure has been predicted. PMID: 12595900
    3. IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action PMID: 12730241
    4. Results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development. PMID: 16820412
    5. IRS-5 (DOK4) is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells PMID: 17443497
    6. Epigenetic regulation of DOK4 expression is associated with non-small-cell lung cancer. PMID: 19073520
    7. Dok-4 represents a novel negative regulator of T cells PMID: 19494292

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  • 蛋白家族：
    DOK family, Type B subfamily
  • 组织特异性：
    Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
  • 数据库链接：

    HGNC: 19868

    OMIM: 608333

    KEGG: hsa:55715

    STRING: 9606.ENSP00000344277

    UniGene: Hs.279832