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DOK5 Antibody

  • 货号：
    CSB-PA007111LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA007111LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western blot
      All lanes: DOK5 antibody at 2µg/ml + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 36, 23 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007111LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DOK5 Polyclonal antibody
  • Uniprot No.：
    Q9P104
  • 基因名：
    DOK5
  • 别名：
    chromosome 20 open reading frame 180 antibody; Docking protein 5 antibody; DOK 5 antibody; DOK5 antibody; DOK5 protein antibody; DOK5_HUMAN antibody; Downstream of tyrosine kinase 5 antibody; Insulin receptor substrate 6 antibody; IRS-6 antibody; IRS6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Docking protein 5 protein (1-198AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DOK5 Antibody (CSB-PA007111LA01HU)，的标记方式是Non-conjugated。对于DOK5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007111LB01HU DOK5 Antibody, HRP conjugated ELISA
    FITC CSB-PA007111LC01HU DOK5 Antibody, FITC conjugated
    Biotin CSB-PA007111LD01HU DOK5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 基因功能参考文献：
    1. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. PMID: 24551065
    2. Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD. PMID: 20215924
    3. identified DOK5 as a novel susceptibility gene for obesity and type 2 diabetes in North Indian subjects PMID: 20187968
    4. DOK5 expression in human T cells, its genomic structure characterized, and its regulation upon T cell activation has been demonstrated. PMID: 12595900
  • 蛋白家族：
    DOK family, Type B subfamily
  • 组织特异性：
    Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 数据库链接：

    HGNC: 16173

    OMIM: 608334

    KEGG: hsa:55816

    STRING: 9606.ENSP00000262593

    UniGene: Hs.473133