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DPF2 Antibody

  • 货号：
    CSB-PA002189
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using DPF2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q92785
  • 基因名：
    DPF2
  • 别名：
    Apoptosis response zinc finger protein antibody; BAF45D antibody; BRG1-associated factor 45D antibody; D4 antibody; D4 zinc and double PHD fingers family 2 antibody; Double PHD fingers 2 antibody; double PHD fingers family 2 antibody; DPF 2 antibody; DPF2 antibody; MGC10180 antibody; Protein requiem antibody; REQ antibody; REQU_HUMAN antibody; Requiem antibody; Requiem apoptosis response zinc finger antibody; UBI D4 antibody; ubi-d4 antibody; UBID 4 antibody; UBID4 antibody; zinc and double PHD fingers family 2 antibody; Zinc finger protein ubi d4 antibody; Zinc finger protein ubi-d4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DPF2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway.
  • 基因功能参考文献：
    1. de novo variants in DPF2 cause Coffin-Siris syndrome and propose a dominant-negative mechanism of pathogenicity. PMID: 29429572
    2. s show that DPF2 interacts with the acetylated tails of both histones 3 and 4 via bipartite binding pockets on the DPF2 surface. Blocking these interactions through targeted mutagenesis of DPF2 abolishes its recruitment to target chromatin regions as well as its ability to prevent myeloid differentiation in vivo. PMID: 28533407
    3. Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity. PMID: 28404846
    4. The demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylation with the strongest preference for propionylation (Kcr). PMID: 27775714
    5. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated. PMID: 26571505
    6. DPF2 decreases monomeric and mono-ubiquitinated OCT4, assembles poly-ubiquitin chains on OCT4 mainly through Ub-K48 linkage PMID: 26417682
    7. crystal structure of the C2H2-type zinc finger domain of human DPF2 with a canonical C2H2 fold, which contains two beta strands and one alpha helix, was reported. PMID: 21888896
    8. found that targeting Requiem and Alg-2 did not result in extended culture viability, but resulted in an increase in maximum viable cell numbers and cumulative IVCD under fed-batch conditions PMID: 20571937

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Requiem/DPF family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 9964

    OMIM: 601671

    KEGG: hsa:5977

    STRING: 9606.ENSP00000436901

    UniGene: Hs.13495