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DPP9 Antibody

  • 货号：
    CSB-PA769770LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA769770LA01HU diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DPP9 Polyclonal antibody
  • Uniprot No.：
    Q86TI2
  • 基因名：
    DPP9
  • 别名：
    Dipeptidyl peptidase 9 antibody; Dipeptidyl peptidase IV related protein 2 antibody; Dipeptidyl peptidase IV-related protein 2 antibody; Dipeptidyl peptidase IX antibody; Dipeptidyl peptidase like protein 9 antibody; Dipeptidyl peptidase-like protein 9 antibody; Dipeptidylpeptidase 9 antibody; Dipeptidylpeptidase IX antibody; DKFZp762F117 antibody; DP 9 antibody; DP9 antibody; DPLP 9 antibody; DPLP9 antibody; DPP 9 antibody; DPP IX antibody; DPP9 antibody; DPP9_HUMAN antibody; DPRP 2 antibody; DPRP-2 antibody; DPRP2 antibody; FLJ16073 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dipeptidyl peptidase 9 protein (289-437AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DPP9 Antibody (CSB-PA769770LA01HU)，的标记方式是Non-conjugated。对于DPP9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA769770LB01HU DPP9 Antibody, HRP conjugated ELISA
    FITC CSB-PA769770LC01HU DPP9 Antibody, FITC conjugated
    Biotin CSB-PA769770LD01HU DPP9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
  • 基因功能参考文献：
    1. The data of this study have shown that fibroblasts and keratinocytes of normal skin endogenously express DPP9 both at transcriptional and protein level. It is localized intracellularly, mostly in cytoplasm, whereby the sub-localization within Golgi is very scarce. PMID: 27682012
    2. DPP9 has a role in promoting tumorgenicity, metastasis and the prediction of poor prognosis in non-small cell lung cancer PMID: 27943262
    3. The DPP9 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP9. PMID: 25464020
    4. There was a concomitant decrease in the phosphorylation of focal adhesion kinase and paxillin, indicating that DPP9 knockdown or enzyme inhibition suppressed the associated adhesion signaling pathway, causing impaired cell movement. PMID: 25486458
    5. Whereas DPP9-short is present in the cytosol, DPP9-long localizes preferentially to the nucleus. PMID: 24562348
    6. DPP9 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
    7. DPP9 binds to SUMO1 through a novel SUMO1 interacting motif. PMID: 23152501
    8. residues important for dimer formation and enzymatic activity PMID: 22001206
    9. These findings suggest an important signaling role of DPP9 in the regulation of survival and proliferation pathways. PMID: 21622624
    10. This is the first study to demonstrate the presence of DP9 in chronic lymphocytic leukemia. PMID: 20534982
    11. identification of two forms, their tissue distribution, cytoplasmic localization PMID: 15245913
    12. cells overexpressing DP9 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
    13. The DPP9 gene is not associated with the occurrence or curve severity of AIS. It is neither a disease-predisposition nor a disease-modifying gene of AIS. PMID: 18940951
    14. results indicate that the biochemical property of DPP9 is very similar to that of DPP8, its homologous protease. DPP9 and DPP8 are likely redundant proteins carrying out overlapping functions in vivo PMID: 19268648
    15. DPP9, a poorly characterized cytoplasmic prolyl-peptidase, is rate-limiting for destruction of proline-containing substrates both in cell extracts and in intact cells PMID: 19667070

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Nucleus.
  • 蛋白家族：
    Peptidase S9B family, DPPIV subfamily
  • 组织特异性：
    Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
  • 数据库链接：

    HGNC: 18648

    OMIM: 608258

    KEGG: hsa:91039

    STRING: 9606.ENSP00000262960

    UniGene: Hs.515081