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DPYSL5 Antibody

  • 货号：
    CSB-PA007173GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BPU6
  • 基因名：
    DPYSL5
  • 别名：
    Collapsin response mediator protein 5 antibody; CRAM antibody; CRMP 3 associated molecule antibody; CRMP 5 antibody; CRMP3 associated molecule antibody; Dihydropyrimidinase like 5 antibody; Dihydropyrimidinase related protein 5 antibody; Dihydropyrimidinase-related protein 5 antibody; DPYL5_HUMAN antibody; DPYS L5 antibody; DPYSL 5 antibody; DPYSL5 antibody; DRP 5 antibody; DRP5 antibody; FLJ45383 antibody; Ulip 6 antibody; Ulip6 antibody; ULIP6 protein antibody; UNC33-like phosphoprotein 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DPYSL5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have a function in neuronal differentiation and/or axon growth.
  • 基因功能参考文献：
    1. Study describes the relevance of DRP5 during osteosarcoma development. DRP5 was upregulated in osteosarcoma specimens and cell lines and shown to function via the downstream MMPs. Inhibition of DRP5 suppressed the growth of cancer cells in vitro and in vivo, and high expression levels of DRP5 were associated with poor prognosis in osteosarcoma patients. PMID: 28374915
    2. Our findings suggest that CRMP5 serves as a major mediator of Notch signaling and Akt activation by controlling the degradation of the Notch receptor, with implications for defining a biomarker signature in glioblastoma PMID: 26122847
    3. present study suggested that CRAM could be a clinical prognostic marker for patients with cervical cancer PMID: 24695578
    4. study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function. PMID: 24324268
    5. identified residues that are crucial for determining the preference for hetero-oligomer or homo-oligomer formation. In spite of being the CRMP family member most closely related to dihydropyrimidinase, CRMP-5 does not have amidohydrolase activity. PMID: 23373749
    6. New CRMP5 isoform present in the nucleus is associated with Glioma. PMID: 23298946
    7. CRMP-5-IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells. PMID: 12838519
    8. CRMP-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk. PMID: 18306241
    9. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of paraneoplastic optic neuropathy secondary to lung cancer marked by an extremely high titer of CRMP-5 antibody. PMID: 18347453
    10. findings point at CRMP5 as a novel marker for distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers. PMID: 18769332
    11. patients with CV2/CRMP5-Ab and thymoma developed myasthenic syndrome more frequently PMID: 18931014

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 数据库链接：

    HGNC: 20637

    OMIM: 608383

    KEGG: hsa:56896

    STRING: 9606.ENSP00000288699

    UniGene: Hs.299315