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DRAM2 Antibody

  • 货号：
    CSB-PA866601ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA866601ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA866601ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA866601ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DRAM2 Polyclonal antibody
  • Uniprot No.：
    Q6UX65
  • 基因名：
    DRAM2
  • 别名：
    DRAM2; TMEM77; PSEC0031; UNQ154/PRO180; DNA damage-regulated autophagy modulator protein 2; Transmembrane protein 77
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DNA damage-regulated autophagy modulator protein 2 protein (182-266AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
  • 基因功能参考文献：
    1. Mycobacterium tuberculosis significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3'-untranslated region of DRAM2. PMID: 27764573
    2. Genetic variants on chromosome 1p13.3 near the damage-regulated autophagy modulator 2 gene DRAM2 associated with Non-ST Elevation Myocardial Infarction (rs656843; odds ratio 1.57, P = 3.11 x 10(-10)) in the case-control analysis. PMID: 26509668
    3. Recessive variants in DRAM2, an autophagy regulator gene, have been recently identified as a cause of retinal dystrophy with early macular involvement PMID: 26720460
    4. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. PMID: 25983245
    5. The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. PMID: 21584698
    6. reduced expression of DRAM2 may contribute to enhanced cell survival in tumor cells. PMID: 19895784
    7. DRAM2 is different from DRAM as it not induced by p53 or p73. DRAM2 is also a lysosomal protein, its overexpression does not modulate autophagy. PMID: 19556885

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane.
  • 蛋白家族：
    DRAM/TMEM150 family
  • 组织特异性：
    Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.
  • 数据库链接：

    HGNC: 28769

    OMIM: 613360

    KEGG: hsa:128338

    UniGene: Hs.485606