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DRAP1 Antibody

  • 货号：
    CSB-PA007177GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14919
  • 基因名：
    DRAP1
  • 别名：
    DR1 associated corepressor antibody; DR1 associated protein 1 (negative cofactor 2 alpha) antibody; DR1 associated protein 1 antibody; DR1 associated protein1 antibody; Dr1-associated corepressor antibody; Dr1-associated protein 1 antibody; DRAP 1 antibody; Drap1 antibody; NC 2 alpha antibody; NC 2alpha antibody; NC2 alpha antibody; NC2-alpha antibody; NC2A_HUMAN antibody; Negative co-factor 2-alpha antibody; Negative cofactor 2 alpha antibody; Negative cofactor 2alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DRAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
  • 基因功能参考文献：
    1. Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly. PMID: 12477712
    2. physical cooperation between BTAF1 and NC2alpha in TBP regulation PMID: 15509807
    3. The global distribution of DRAP1 on promoters was determined. PMID: 17548813
    4. provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode PMID: 17994103
    5. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NC2 alpha/DRAP1 family
  • 组织特异性：
    Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
  • 数据库链接：

    HGNC: 3019

    OMIM: 602289

    KEGG: hsa:10589

    STRING: 9606.ENSP00000307850

    UniGene: Hs.356742