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DSE Antibody

  • 货号：
    CSB-PA890925LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of U251 cells using CSB-PA890925LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA890925LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA890925LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DSE Polyclonal antibody
  • Uniprot No.：
    Q9UL01
  • 基因名：
  • 别名：
    Chondroitin glucuronate 5 epimerase antibody; Chondroitin-glucuronate 5-epimerase antibody; Dermatan sulfate epimerase antibody; Dermatan-sulfate epimerase antibody; DS epimerase antibody; DSE antibody; DSE_HUMAN antibody; DSEPI antibody; OTTHUMP00000040406 antibody; SART 2 antibody; SART-2 antibody; Squamous cell carcinoma antigen recognized by T cells 2 antibody; Squamous cell carcinoma antigen recognized by T-cells 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dermatan-sulfate epimerase protein (23-270AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DSE Antibody (CSB-PA890925LA01HU)，的标记方式是Non-conjugated。对于DSE Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA890925LB01HU DSE Antibody, HRP conjugated ELISA
    FITC CSB-PA890925LC01HU DSE Antibody, FITC conjugated
    Biotin CSB-PA890925LD01HU DSE Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
  • 基因功能参考文献：
    1. Study showed that DSE is frequently upregulated in human glioma tissue and cell lines and associated with a worse tumor grade and poor overall survival. Its knockdown suppresses malignant phenotypes, whereas DSE overexpression enhances glioma cell malignancy, both in vitro and in vivo. Mechanically, DSE modulates HB-EGF-induced EGFR/ErbB2 activity and downstream signaling. PMID: 29864158
    2. study identified a homozygous DSE missense mutation (c.803C>T, p.S268L) in a male child with musculocontractural type of Ehlers-Danlos syndrome; data indicate mutation affects the epimerase activity, resulting in reduced dermatan sulfate (DS) biosynthesis and an increased synthesis or an accumulation or reduced conversion of chondroitin sulfate PMID: 23704329
    3. Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma PMID: 22350411
    4. Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. PMID: 19004833
  • 相关疾病：
    Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dermatan-sulfate isomerase family
  • 组织特异性：
    Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Exp
  • 数据库链接：

    HGNC: 21144

    OMIM: 605942

    KEGG: hsa:29940

    STRING: 9606.ENSP00000332151

    UniGene: Hs.458358