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DSTYK Antibody

  • 货号：
    CSB-PA657435
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA657435(DSTYK Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6XUX3
  • 基因名：
    DSTYK
  • 别名：
    DSTYK antibody; Dual serine/threonine and tyrosine protein kinase antibody; Dusty PK antibody; Dusty protein kinase antibody; DUSTY_HUMAN antibody; HDCMD38P antibody; KIAA0472 antibody; Receptor interacting protein 5 antibody; Receptor interacting protein kinase 5 antibody; Receptor interacting serine/threonine protein kinase 5 antibody; Receptor-interacting serine/threonine-protein kinase 5 antibody; RIP homologous kinase antibody; RIP-homologous kinase antibody; RIP5 antibody; RIPK5 antibody; SgK496 antibody; Sugen kinase 496 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human DSTYK
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
  • 基因功能参考文献：
    1. RIPK3 promotes adenovirus type 5 oncolytic activity. PMID: 29238045
    2. we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK in all four affected family members with Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 PMID: 28157540
    3. We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. PMID: 23862974
    4. Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. PMID: 17123648
  • 相关疾病：
    Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 组织特异性：
    Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional
  • 数据库链接：

    HGNC: 29043

    OMIM: 270750

    KEGG: hsa:25778

    STRING: 9606.ENSP00000356130

    UniGene: Hs.6874