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DTX1 Antibody

  • 货号：
    CSB-PA114923
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA114923(DTX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q86Y01
  • 基因名：
  • 别名：
    Deltex 1; E3 ubiquitin ligase antibody; Deltex antibody; Deltex homolog 1 (Drosophila) antibody; Deltex homolog 1 antibody; Deltex protein 1 antibody; Deltex-1 antibody; Deltex1 antibody; dtx1 antibody; DTX1_HUMAN antibody; E3 ubiquitin protein ligase DTX1 antibody; E3 ubiquitin-protein ligase DTX1 antibody; FXI-T1 antibody; Fxit 1 antibody; Fxit1 antibody; hDTX1 antibody; hDx 1 antibody; mDTX1 antibody; Protein deltex 1 antibody; Protein deltex-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human DTX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
  • 基因功能参考文献：
    1. Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma PMID: 28183850
    2. PI5P4Kgamma positively regulates the DTX1-mediated Notch pathway by promoting receptor recycling PMID: 29440432
    3. Data indicate that decreased expression of deltex E3 ubiquitin ligase 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH pathway activation and increased migration potential. PMID: 28146432
    4. Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination. PMID: 26894927
    5. this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. PMID: 23395680
    6. characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6 PMID: 12617994
    7. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. PMID: 12670957

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
  • 蛋白家族：
    Deltex family
  • 组织特异性：
    Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
  • 数据库链接：

    HGNC: 3060

    OMIM: 602582

    KEGG: hsa:1840

    STRING: 9606.ENSP00000257600

    UniGene: Hs.372152