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DTX4 Antibody

  • 货号：
    CSB-PA764784LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA764784LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DTX4 Polyclonal antibody
  • Uniprot No.：
    Q9Y2E6
  • 基因名：
  • 别名：
    Deltex4 antibody; Dtx4 antibody; DTX4_HUMAN antibody; E3 ubiquitin-protein ligase DTX4 antibody; Protein deltex-4 antibody; RING finger protein 155 antibody; RNF155 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase DTX4 protein (167-432AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DTX4 Antibody (CSB-PA764784LA01HU)，的标记方式是Non-conjugated。对于DTX4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA764784LB01HU DTX4 Antibody, HRP conjugated ELISA
    FITC CSB-PA764784LC01HU DTX4 Antibody, FITC conjugated
    Biotin CSB-PA764784LD01HU DTX4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
  • 基因功能参考文献：
    1. Notch is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing PMID: 28611181
    2. Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Deltex family
  • 数据库链接：

    HGNC: 29151

    OMIM: 616110

    KEGG: hsa:23220

    STRING: 9606.ENSP00000227451

    UniGene: Hs.523696