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DUSP16 Antibody

  • 货号：
    CSB-PA060192
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BY84
  • 基因名：
  • 别名：
    Dual specificity phosphatase 16 antibody; Dual specificity protein phosphatase 16 antibody; DUS16_HUMAN antibody; DUSP 16 antibody; DUSP16 antibody; KIAA1700 antibody; MAP kinase phosphatase 7 antibody; MAPK phosphatase 7 antibody; Mitogen activated protein kinase phosphatase 7 antibody; Mitogen-activated protein kinase phosphatase 7 antibody; MKP 7 antibody; MKP-7 antibody; MKP7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human MKP-7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
  • 基因功能参考文献：
    1. The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported. PMID: 26988444
    2. The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci. PMID: 26381291
    3. analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha PMID: 23926106
    4. PPARdelta-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK signaling. PMID: 23639976
    5. Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
    6. MKP-7, a negative regulator of JNK, regulates VCAM-1 expression in activated endothelial cells through IRF-1 but not GATA6. PMID: 22182512
    7. DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
    8. DUSP16 is a new epigenetically regulated determinant of JNK activation in BL. PMID: 20551953
    9. MKP-7 down-regulates ERK-dependent gene expression by blocking nuclear accumulation of phospho-ERK. PMID: 20122898
    10. context-dependent role for DUSP16 on cell transformation and apoptosis. PMID: 14586399
    11. activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation PMID: 15689616
    12. MKP7 binds beta-arrestin 2 via amino acids 394-443 of MKP7, the same region that interacts with JIP-1 PMID: 15888437
    13. identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration PMID: 19307591

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 数据库链接：

    HGNC: 17909

    OMIM: 607175

    KEGG: hsa:80824

    STRING: 9606.ENSP00000228862

    UniGene: Hs.536535