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DUSP5 Antibody

  • 货号：
    CSB-PA620976LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA620976LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DUSP5 Polyclonal antibody
  • Uniprot No.：
    Q16690
  • 基因名：
  • 别名：
    Dual specificity phosphatase 5 antibody; Dual specificity protein phosphatase 5 antibody; Dual specificity protein phosphatase hVH 3 antibody; Dual specificity protein phosphatase hVH3 antibody; DUS5_HUMAN antibody; DUSP 5 antibody; DUSP antibody; DUSP5 antibody; HVH 3 antibody; HVH3 antibody; Serine/threonine specific protein phosphatase antibody; VH 3 antibody; VH1 like phosphatase 3 antibody; VH3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dual specificity protein phosphatase 5 protein (56-181AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DUSP5 Antibody (CSB-PA620976LA01HU)，的标记方式是Non-conjugated。对于DUSP5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA620976LB01HU DUSP5 Antibody, HRP conjugated ELISA
    FITC CSB-PA620976LC01HU DUSP5 Antibody, FITC conjugated
    Biotin CSB-PA620976LD01HU DUSP5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
  • 基因功能参考文献：
    1. Methylation the DUSP5 gene promoter can serve as an additional means of identifying CIMP-high colorectal cancers. PMID: 29379130
    2. DUSP5 expression in skeletal muscle was ninefold higher immediately after exercise and returned to pre-exercise level within 2 h. PMID: 28989118
    3. Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. PMID: 26967242
    4. Results show that DUSP5 and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion. PMID: 28910386
    5. role of the secondary binding site in assembling the DUSP5-pERK pre-reactive complex was further demonstrated by molecular dynamics simulations that showed that the remote C197-C219 disulfide linkage controls the structure of the secondary binding pocket based on its redox state (i.e., disulfide/dithiol) and, in turn, the enzymatic activity of DUSP5 PMID: 27739308
    6. The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein. PMID: 25519881
    7. Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells. PMID: 24651368
    8. DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples. PMID: 23402999
    9. Studies indicate that dual-specificity MAP kinase phosphatases (MKPs) DUSP6/MKP-3 and DUSP5 are localized in the cytoplasm and nuclear compartments. PMID: 22812510
    10. DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation. PMID: 20806045
    11. the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
    12. In FD-Fms cells, overexpression of human DUSP5 increased M-CSF-dependent proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increased M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiation. PMID: 19801501
    13. DUSP5 is a direct target of p53. PMID: 12944906
    14. DUSP5 inactivates ERK2 and causes both nuclear translocation and sequestration of inactive ERK2. PMID: 15713638
    15. the crystal structure of the catalytic domain of DUSP5 in an active conformation. PMID: 17078075
    16. proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 actions, and tolerance PMID: 18430737
    17. mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease. PMID: 18927432

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 数据库链接：

    HGNC: 3071

    OMIM: 603069

    KEGG: hsa:1847

    STRING: 9606.ENSP00000358596

    UniGene: Hs.2128