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  4. DUSP9 Antibody

DUSP9 Antibody

  • 货号：
    CSB-PA007849
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO cells using MKP-4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99956
  • 基因名：
  • 别名：
    Dual specificity phosphatase 9 antibody; Dual specificity protein phosphatase 9 antibody; DUS9_HUMAN antibody; DUSP9 antibody; MAP kinase phosphatase 4 antibody; Mitogen activated protein kinase phosphatase 4 antibody; Mitogen-activated protein kinase phosphatase 4 antibody; MKP 4 antibody; MKP-4 antibody; MKP4 antibody; serine/threonine specific protein phosphatase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MKP-4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inactivates MAP kinases. Has a specificity for the ERK family.
  • 基因功能参考文献：
    1. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells. PMID: 25998184
    2. A possible use for DUSP9 as CIMP marker. PMID: 24838152
    3. DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia. PMID: 23276385
    4. The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes. PMID: 23029454
    5. decreased expression of DUSP-9 is associated with poor prognosis in ccRCC. PMID: 21943117
    6. 2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented PMID: 21206059
    7. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP PMID: 18006813

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 数据库链接：

    HGNC: 3076

    OMIM: 300134

    KEGG: hsa:1852

    STRING: 9606.ENSP00000345853

    UniGene: Hs.144879