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DYNC1LI2 Antibody

  • 货号：
    CSB-PA007296GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43237
  • 基因名：
    DYNC1LI2
  • 别名：
    Cytoplasmic dynein 1 light intermediate chain 2 antibody; cytosolic antibody; DC1L2_HUMAN antibody; DNCLI2 antibody; Dync1li2 antibody; Dynein cytoplasmic 1 light intermediate chain 2 antibody; Dynein light intermediate chain 2 antibody; dynein light intermediate chain 2 cytosolic antibody; dynein; cytoplasmic; light intermediate polypeptide 2 antibody; LIC-2 antibody; LIC2 antibody; LIC53/55 antibody; OTTHUMP00000174820 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DYNC1LI2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
  • 基因功能参考文献：
    1. Cortically localized dynein, essential for maintaining correct spindle orientation, consists majorly of LIC2-dynein, which interacts with cortical 14-3-3 epsilon- zeta and Par3, conserved proteins required for orienting the spindle. PMID: 28003657
    2. This study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein. PMID: 27441562
    3. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
    4. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
    5. FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2. PMID: 20214888

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Dynein light intermediate chain family
  • 数据库链接：

    HGNC: 2966

    OMIM: 611406

    KEGG: hsa:1783

    STRING: 9606.ENSP00000258198

    UniGene: Hs.369068