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DYNC2LI1 Antibody

  • 货号：
    CSB-PA844722ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DYNC2LI1 antibody at 1.17µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: A549 whole cell lysate
      Lane 3: Mouse gonadal tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 40, 38, 23, 16 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA844722ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA844722ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DYNC2LI1 Polyclonal antibody
  • Uniprot No.：
    Q8TCX1
  • 基因名：
    DYNC2LI1
  • 别名：
    CGI-60 antibody; Cytoplasmic dynein 2 light intermediate chain 1 antibody; D2LIC antibody; DC2L1_HUMAN antibody; DYNC2LI1 antibody; Dynein 2 light intermediate chain antibody; Dynein, cytoplasmic 2, light intermediate chain 1 antibody; LIC3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 protein (1-352AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length.
  • 基因功能参考文献：
    1. depletion of DYNC2LI1 induced altered cilia morphology with broadened ciliary tips and accumulation of intraflagellar transport complexes (IFT-B) complex proteins in accordance with retrograde IFT defects. PMID: 26130459
    2. DYNC2LI1 is essential for dynein-2 complex stability and that mutations in DYNC2LI1 result in variable length, including hyperelongated, cilia, Hedgehog pathway impairment and ciliary IFT accumulations, causing short rib polydactyly syndrome. PMID: 26077881
  • 相关疾病：
    Short-rib thoracic dysplasia 15 with polydactyly (SRTD15)
  • 亚细胞定位：
    Golgi apparatus. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Dynein light intermediate chain family
  • 组织特异性：
    Expressed in bone, brain, kidney, and cartilage. Lower expression in heart, liver, lung, placenta and thymus.
  • 数据库链接：

    HGNC: 24595

    OMIM: 617083

    KEGG: hsa:51626

    STRING: 9606.ENSP00000260605

    UniGene: Hs.371597