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DYNLRB1 Antibody

  • 货号：
    CSB-PA865093HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA865093HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DYNLRB1 Polyclonal antibody
  • Uniprot No.：
    Q9NP97
  • 基因名：
    DYNLRB1
  • 别名：
    DYNLRB1 antibody; BITH antibody; DNCL2A antibody; DNLC2A antibody; ROBLD1 antibody; HSPC162Dynein light chain roadblock-type 1 antibody; Bithoraxoid-like protein antibody; BLP antibody; Dynein light chain 2A antibody; cytoplasmic antibody; Dynein-associated protein Km23 antibody; Roadblock domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dynein light chain roadblock-type 1 protein (3-96AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DYNLRB1 Antibody (CSB-PA865093HA01HU)，的标记方式是Non-conjugated。对于DYNLRB1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865093HB01HU DYNLRB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA865093HC01HU DYNLRB1 Antibody, FITC conjugated
    Biotin CSB-PA865093HD01HU DYNLRB1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
  • 基因功能参考文献：
    1. Human colorectal carcinoma cells display decreased tumor progression and invasion when a novel anti-cell motility target, DYNLRB1, is being silenced. PMID: 23755307
    2. TGFbeta regulates km23-1 interaction with the R1beta regulatory subunit of protein kinase A. PMID: 23333499
    3. these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy. PMID: 23079622
    4. km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways PMID: 22637579
    5. Silencing of km23, either through somatic genetic mutation or promoter hypermethylation, is rare in ovarian, breast, and colorectal cancers. PMID: 16778097
    6. report the 2.1-A crystal structure of Dnlc2A using single anomalous diffraction PMID: 16970917
    7. Infrequently mutated in human colorectal and gastric cancers. PMID: 17556076
    8. DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
    9. Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. PMID: 19571232

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    GAMAD family
  • 组织特异性：
    High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.
  • 数据库链接：

    HGNC: 15468

    OMIM: 607167

    KEGG: hsa:83658

    STRING: 9606.ENSP00000349679

    UniGene: Hs.593920