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EDC3 Antibody

  • 货号：
    CSB-PA007393GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96F86
  • 基因名：
    EDC3
  • 别名：
    EDC 3 antibody; edc3 antibody; EDC3_HUMAN antibody; enhancer of mRNA decapping 3 homolog (S. cerevisiae) antibody; Enhancer of mRNA decapping 3 homolog antibody; Enhancer of mRNA decapping 3; S. cerevisiae; homolog of antibody; Enhancer of mRNA decapping protein 3 antibody; Enhancer of mRNA-decapping protein 3 antibody; FLJ21128 antibody; FLJ31777 antibody; hYjeF_N2 antibody; hYjeF_N2-15q23 antibody; LSM 16 antibody; LSM16 antibody; LSM16 homolog (EDC3 S. cerevisiae) antibody; LSM16 homolog (EDC3; S. cerevisiae) antibody; LSM16 homolog antibody; YJDC antibody; YjeF domain containing antibody; YjeF domain containing protein 1 antibody; YjeF domain containing protein antibody; YjeF domain-containing protein 1 antibody; YjeF N-terminal domain-containing protein 2 antibody; YjeF_N2 antibody; YJEFN2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EDC3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
  • 基因功能参考文献：
    1. In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentration. PMID: 25701870
    2. The modular architecture enables EDC3 to interact with multiple components of the decapping machinery, including DCP1, DCP2, and Me31B. PMID: 17923697
    3. The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation PMID: 18678652
    4. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. PMID: 19285948
  • 相关疾病：
    Mental retardation, autosomal recessive 50 (MRT50)
  • 亚细胞定位：
    Cytoplasm, P-body. Note=Processing bodies (PB).
  • 蛋白家族：
    EDC3 family
  • 组织特异性：
    Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland.
  • 数据库链接：

    HGNC: 26114

    OMIM: 609842

    KEGG: hsa:80153

    STRING: 9606.ENSP00000320503

    UniGene: Hs.682454