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EED Antibody

  • 货号：
    CSB-PA007408GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75530
  • 基因名：
    EED
  • 别名：
    eed antibody; EED protein antibody; EED; mouse; homolog of antibody; EED_HUMAN antibody; Embryonic ectoderm development antibody; Embryonic ectoderm development isoform a antibody; Embryonic ECTODERM development protein homolog antibody; Embryonic ectoderm development protein; mouse; homolog of antibody; hEED antibody; OTTHUMP00000235483 antibody; OTTHUMP00000235484 antibody; OTTHUMP00000235485 antibody; Polycomb protein eed antibody; WAIT 1 antibody; WAIT-1 antibody; WAIT1 antibody; WD protein associating with integrin cytoplasmic tails 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human EED
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IP,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
  • 基因功能参考文献：
    1. we present a patient with a clinical diagnosis of Weaver syndrome and novel de novo sequence variant in EED. Our observation together with previous reports [2, 3, 5] suggests that EED gene testing is warranted in patients with the overgrowth syndrome features and suspicion of Weaver syndrome with normal results for EZH2 gene sequencing. PMID: 29410511
    2. Data suggest the polycomb repressive complex 2 subunits EZH2, SUZ12, and EED protein axis as promising therapeutic target for treating sarcoma. PMID: 29415665
    3. These findings support that Weaver syndrome is a disorder with locus heterogeneity and can be due to pathogenic variants in either EZH2 or EED. This case highlights the utility of exome sequencing as a clinical diagnostic tool for novel gene discovery as well as the importance of re-examination of exome data as new information about gene-disease associations becomes available. PMID: 27868325
    4. we have found two unrelated families of different ethnicities, with a similar rare phenotype, both associated with de novo mutations in this member of the PRC2 complex, we are confident that EED is indeed a novel overgrowth gene. PMID: 27193220
    5. Mutations of SUZ12 and EED are reported to have tumor suppressive functions. (Review) PMID: 27000413
    6. These results suggest that the SNPs of the EED gene might not be associated with susceptibility to CRC. PMID: 23709348
    7. An integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2, is reported. PMID: 24457600
    8. Data show that overall enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC) tissues was significantly increased than in the non-cancerous tissue. PMID: 25326896
    9. EED, a component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (H3K27), was involved in epithelial-mesenchymal transition (EMT) of cancer cells induced by Transforming Growth Factor-beta (TGF-beta). PMID: 25264103
    10. Polycomb repressive complex 2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. PMID: 25240281
    11. EZH2-EED is necessary and sufficient for binding to the lncRNA HOTAIR. PMID: 24320048
    12. Although inactivating mutations in PRC2-encoding genes EZH2, EED, and SUZ12 are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mutations in EZH2 are frequently observed in B-cell lymphoma. PMID: 23982173
    13. EED mutants impair polycomb repressive complex 2 and is associated with myelodysplastic syndrome and related neoplasms PMID: 22733077
    14. Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis. PMID: 22271413
    15. Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies. PMID: 22308284
    16. The s found that Sox2 and Eed positively regulate each other's expression and contribute to the maintenance of self-renewal in embryonic stem cells by controlling histone methylation and acetylation. PMID: 21540835
    17. molecular basis of EED-methyllysine recognition, and the biochemical characterization of how the activity of a histone methyltransferase is oppositely regulated by two histone marks. PMID: 20974918
    18. histone modification including PRC2-mediated repressive histone marker H3K27me3 and active histone marker acH4 may involve in CD11b transcription during HL-60 leukemia cells reprogramming to terminal differentiation[polycomb repressive complex 2 ] PMID: 19578722
    19. EED is a nuclear factor and repressor of transcription and is recruited to the plasma membrane by HIV-1 nef PMID: 14759364
    20. EED exerted an antiviral activity at the late stage of HIV-1 replication, which included genomic RNA packaging and virus assembly, resulting possibly from a mistrafficking of viral genomic RNA (gRNA) or gRNA/Gag complex. PMID: 17547741
    21. NIPP1 is present in a complex with EED and EZH2 in vivo and has distinct binding sites for these proteins. PMID: 17804093
    22. Identification of antibody-, MA-, IN- and EZH2-binding sites at EED's surface provides a global picture of the immunogenic and protein-protein interacting regions in the EED C-terminal domain, organized as a seven-bladed beta-propeller protein. PMID: 18302803
    23. the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and this leads to the allosteric activation of the methyltransferase activity of PRC2. PMID: 19767730

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  • 相关疾病：
    Cohen-Gibson syndrome (COGIS)
  • 亚细胞定位：
    Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
  • 蛋白家族：
    WD repeat ESC family
  • 组织特异性：
    Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
  • 数据库链接：

    HGNC: 3188

    OMIM: 605984

    KEGG: hsa:8726

    STRING: 9606.ENSP00000263360

    UniGene: Hs.503510