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EFNB3 Antibody

  • 货号：
    CSB-PA007935
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of SKOV3 cells using Ephrin-B3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15768
  • 基因名：
    EFNB3
  • 别名：
    EFL 6 antibody; EFL6 antibody; EFNB 3 antibody; Efnb3 antibody; EFNB3_HUMAN antibody; EPH related receptor transmembrane ligand ELK L3 antibody; EPH related receptor transmembrane ligand ELKL3 antibody; EPH related receptor tyrosine kinase ligand 8 antibody; EPH-related receptor transmembrane ligand ELK-L3 antibody; EPH-related receptor tyrosine kinase ligand 8 antibody; Ephrin B3 antibody; Ephrin-B3 antibody; EphrinB3 antibody; EPLG 8 antibody; EPLG8 antibody; LERK 8 antibody; LERK-8 antibody; LERK8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Ephrin-B3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.; (Microbial infection) Acts as a receptor for nipah virus and hendra virus.
  • 基因功能参考文献：
    1. The study provides evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrating that EFNB3 is a hypertension risk gene. PMID: 28272517
    2. Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. PMID: 27941904
    3. Data show that Ephrin B3 was concomitantly expressed with EphA2 and Ephrin A1 with higher Ephrin B3 levels found in non-squamous than in squamous tumors. PMID: 27533087
    4. Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy PMID: 26930615
    5. Findings suggest that EphrinB3 may be a relevant target for promoting remyelination in demyelinating disease PMID: 26687980
    6. Ephrin-B3 binds to B lymphocytes, most likely via a non-classical receptor, and induces migration of the memory B cell subpopulation. PMID: 21447033
    7. Phosphoproteomic profiling of nonsmall cell lung cancer cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. PMID: 21413766
    8. evidence for an unknown ephrin-B3-binding cell-surface proteoglycan involved in cellular signalling PMID: 20925654
    9. EphrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity. PMID: 16477309
    10. Immunohistochemistry shows robust staining for phosphorylated ephrin-B and ephrin-B3 in invading glioblastoma cells. PMID: 16951161
    11. Transgenic EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus PMID: 18057206
    12. report the crystal structures of the NiV-G both in its receptor-unbound state and in complex with ephrin-B3, providing, to our knowledge, the first view of a paramyxovirus attachment complex in which a cellular protein is used as the virus receptor PMID: 18632560

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Ephrin family
  • 组织特异性：
    Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
  • 数据库链接：

    HGNC: 3228

    OMIM: 602297

    KEGG: hsa:1949

    STRING: 9606.ENSP00000226091

    UniGene: Hs.26988