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EI24 Antibody

  • 货号：
    CSB-PA099944
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA099944(EI24 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O14681
  • 基因名：
  • 别名：
    EI24; PIG8; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human EI24
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.
  • 基因功能参考文献：
    1. EI24 is an essential player in ubiquitin-proteasome system-autophagy crosstalk via degradation of RING E3 ligases. PMID: 27541728
    2. Low EI24 expression is associated with triple negative breast cancer. PMID: 28038450
    3. Low EI24 and high IGF-1R expressions in lung cancer patients. PMID: 26342551
    4. Findings establish EI24 as a critical suppressor of tumor progression. PMID: 24280371
    5. Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import. PMID: 24821838
    6. Ei24 is a novel E2F1 target gene contributing to the survival of p53-deficient cells upon UVC irradiation and thus may have a potential significance as a therapeutic target of certain chemotherapy for treating p53-deficient tumors. PMID: 24014029
    7. our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX. PMID: 21154811
    8. LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance. PMID: 21803008
    9. identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness PMID: 17981155

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  • 相关疾病：
    EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
  • 亚细胞定位：
    Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    EI24 family
  • 数据库链接：

    HGNC: 13276

    OMIM: 605170

    KEGG: hsa:9538

    STRING: 9606.ENSP00000278903

    UniGene: Hs.643514