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EIF2B2 Antibody

  • 货号：
    CSB-PA007515ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007515ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA007515ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF2B2 Polyclonal antibody
  • Uniprot No.：
    P49770
  • 基因名：
    EIF2B2
  • 别名：
    EI2BB_HUMAN antibody; EIF 2Bbeta antibody; EIF-2Bbeta antibody; EIF2B antibody; EIF2B GDP GTP exchange factor subunit beta antibody; EIF2B2 antibody; EIF2B2 antibody antibody; EIF2BB antibody; Eukaryotic translation initiation factor 2B antibody; Eukaryotic translation initiation factor 2B beta antibody; Eukaryotic translation initiation factor 2B; subunit 2 antibody; Eukaryotic translation initiation factor 2B; subunit 2 beta antibody; Eukaryotic translation initiation factor 2B; subunit 2 beta; 39kDa antibody; S20I15 antibody; S20III15 antibody; Translation initiation factor eIF-2B subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Translation initiation factor eIF-2B subunit beta protein (1-351AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • 基因功能参考文献：
    1. Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs). PMID: 29036434
    2. It would be better to consider Vanishing White Matter Disease as an eIF2B-related multisystem disorder, not just as a neurological disorder. PMID: 28041799
    3. An Italian patient is described with a c.638A>G mutation in exon 5 of EIF2B2 gene with very slow progressive vanishing white matter disease. PMID: 22729508
    4. analysis of vanishing white matter disease caused by EIF2B2 mutation with the presentation of an adrenoleukodystrophy phenotype [case report] PMID: 22285377
    5. Mutation in EIF2B2 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. PMID: 12707859
    6. Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity. PMID: 14993275
    7. The role of the residues Ser2 and Ser67 contribute to the important role of the N-terminal region of eIF2beta for its function in mammals. PMID: 16225457
    8. CACH syndrome is linked to mutations in the five EIF2B--REVIEW PMID: 17878805
    9. Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to >120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon). PMID: 18263758

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  • 相关疾病：
    Leukodystrophy with vanishing white matter (VWM)
  • 蛋白家族：
    EIF-2B alpha/beta/delta subunits family
  • 数据库链接：

    HGNC: 3258

    OMIM: 603896

    KEGG: hsa:8892

    STRING: 9606.ENSP00000266126

    UniGene: Hs.409137