EIF3H Antibody
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货号:CSB-PA007537ESR2HU
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规格:¥440
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促销:
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图片:
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Western blot
All lanes: EIF3H antibody at 7μg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: Rat brain tissue
Lane 3: U251whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa -
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA007537ESR2HU at dilution of 1:100
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) EIF3H Polyclonal antibody
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Uniprot No.:O15372
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基因名:EIF3H
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别名:eIF-3-gamma antibody; eIF3 gamma antibody; eIF3 p40 antibody; eIF3 p40 subunit antibody; eIF3h antibody; EIF3H_HUMAN antibody; EIF3S3 antibody; Eukaryotic translation initiation factor 3 subunit 3 antibody; Eukaryotic translation initiation factor 3 subunit H antibody; MGC102958 antibody
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宿主:Rabbit
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反应种属:Human, Rat
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免疫原:Recombinant Human Eukaryotic translation initiation factor 3 subunit H protein (80-340AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
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基因功能参考文献:
- EIF3H knockdown inhibited cell proliferation and colony formation in gastric cancer lines and led to cell cycle arrest at the G0/G1 phase, while inducing apoptosis via up- and downregulation of pro- and anti-apoptotic factors, respectively. These results indicate that EIF3H can serve as a novel therapeutic target for the clinical treatment of gastric cancer. PMID: 30060823
- EIF3H plays key roles in the apoptosis in colorectal cancer cells, which suggests EIF3H as a potential diagnostic biomarker in colorectal cancer PMID: 30022709
- eukaryotic translation initiation factor 3H has roles in proliferation, invasion and tumorigenicity in human hepatocellular carcinoma PMID: 27340783
- -RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells PMID: 24148822
- Increased expression of EIF3H gene increases colorectal cancer growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association. PMID: 20862326
- Gain of EIF3S3 was associated with poor cancer-specific survival in incidentally found prostate carcinomas. PMID: 11733359
- PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC. PMID: 14578863
- overexpression of EIF3S3 is associated with breast and prostate cancer PMID: 14997205
- results suggest that eukaryotic translation initiation factor 3, subunit 3 (EIF3S3) regulates cell growth and viability, and that overexpression of the gene may provide growth advantage to the cancer cells PMID: 16652384
- high eIF3h levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells. PMID: 18544531
- MYC and EIF3H are frequently coamplified in NSCLC and that a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity. PMID: 19204574
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亚细胞定位:Cytoplasm.
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蛋白家族:EIF-3 subunit H family
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数据库链接:
HGNC: 3273
OMIM: 603912
KEGG: hsa:8667
STRING: 9606.ENSP00000429931
UniGene: Hs.492599
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