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EIF3J Antibody

  • 货号：
    CSB-PA007539LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry analysis of human kidney tissue using CSB-PA007539LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF3J Polyclonal antibody
  • Uniprot No.：
    O75822
  • 基因名：
    EIF3J
  • 别名：
    eIF 3 alpha antibody; eIF-3-alpha antibody; eIF3 alpha antibody; eIF3 p35 antibody; eIF3j antibody; EIF3J_HUMAN antibody; EIF3S 1 antibody; EIF3S1 antibody; Eukaryotic translation initiation factor 3 subunit 1 antibody; Eukaryotic translation initiation factor 3 subunit J antibody; Eukaryotic translation initiation factor 3; subunit 1 (alpha; 35kD) antibody; Eukaryotic translation initiation factor 3; subunit 1 alpha; 35kD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 3 subunit J protein (5-115AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIF3J Antibody (CSB-PA007539LA01HU)，的标记方式是Non-conjugated。对于EIF3J Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007539LB01HU EIF3J Antibody, HRP conjugated ELISA
    FITC CSB-PA007539LC01HU EIF3J Antibody, FITC conjugated
    Biotin CSB-PA007539LD01HU EIF3J Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • 基因功能参考文献：
    1. CK2-phosphorylation of eIF3j at Ser127 promotes the assembly of the eIF3 complex, a crucial step in the activation of the translation initiation machinery. PMID: 25887626
    2. eIF1, eIF1A, eIF3j, and the eIF2-GTP-Met-tRNAi ternary complex stably bind to the 43 S preinitiation complex PMID: 25246524
    3. whether eIF3alpha polymorphism is associated with severe platinum toxicity in patients with non-small cell lung cancer (NSCLC). PMID: 22804784
    4. Beta-Arrestin 2 modulates binding of eIF-3-alpha to selected components of the extracellular signal-regulated kinase pathway. PMID: 22025682
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit J family
  • 数据库链接：

    HGNC: 3270

    OMIM: 603910

    KEGG: hsa:8669

    STRING: 9606.ENSP00000261868

    UniGene: Hs.404056