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EIF4EBP2 Antibody

  • 货号：
    CSB-PA007563DA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA007563DA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIF4EBP2 Polyclonal antibody
  • Uniprot No.：
    Q13542
  • 基因名：
    EIF4EBP2
  • 别名：
    4E-BP2 antibody; 4EBP2 antibody; 4EBP2_HUMAN antibody; eIF4E binding protein 2 antibody; eIF4E-binding protein 2 antibody; Eif4ebp2 antibody; Eukaryotic translation initiation factor 4E binding protein 1 antibody; Eukaryotic translation initiation factor 4E-binding protein 2 antibody; PHASII antibody; phosphorylated; heat and acid stable regulated by insulin protein II antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2 protein (1-120AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIF4EBP2 Antibody (CSB-PA007563DA01HU)，的标记方式是Non-conjugated。对于EIF4EBP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007563DB01HU EIF4EBP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA007563DC01HU EIF4EBP2 Antibody, FITC conjugated
    Biotin CSB-PA007563DD01HU EIF4EBP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • 基因功能参考文献：
    1. molecular dynamics simulations to investigate both the folded and unfolded states of 4E-BP2 under different phosphorylation states of T37 and T46 PMID: 28068774
    2. isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain PMID: 20424163
    3. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin PMID: 14507920
  • 蛋白家族：
    EIF4E-binding protein family
  • 数据库链接：

    HGNC: 3289

    OMIM: 602224

    KEGG: hsa:1979

    STRING: 9606.ENSP00000362314

    UniGene: Hs.621200