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EIPR1 Antibody

  • 货号：
    CSB-PA681508LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA681508LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA681508LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EIPR1 Polyclonal antibody
  • Uniprot No.：
    Q53HC9
  • 基因名：
    EIPR1
  • 别名：
    EIPR1 antibody; TSSC1EARP and GARP complex-interacting protein 1 antibody; Endosome-associated recycling protein-interacting protein antibody; Golgi-associated retrograde protein-interacting protein antibody; Tumor-suppressing STF cDNA 1 protein antibody; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human EARP and GARP complex-interacting protein 1 protein (201-387AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EIPR1 Antibody (CSB-PA681508LA01HU)，的标记方式是Non-conjugated。对于EIPR1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA681508LB01HU EIPR1 Antibody, HRP conjugated ELISA
    FITC CSB-PA681508LC01HU EIPR1 Antibody, FITC conjugated
    Biotin CSB-PA681508LD01HU EIPR1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.
  • 基因功能参考文献：
    1. Fluorescence recovery after photobleaching shows that TSSC1 is required for efficient recruitment of GARP to the TGN. These studies thus demonstrate that TSSC1 plays a critical role in endosomal retrieval pathways as a regulator of both GARP and EARP function. PMID: 27440922
    2. TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. PMID: 23933319
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    WD repeat EIPR1 family
  • 数据库链接：

    HGNC: 12383

    OMIM: 608998

    KEGG: hsa:7260

    STRING: 9606.ENSP00000371559

    UniGene: Hs.502770