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ELF1 Antibody

  • 货号：
    CSB-PA008003
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using Elf-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P32519
  • 基因名：
    ELF1
  • 别名：
    E74 like factor 1 antibody; E74-like factor 1 antibody; ELF 1 antibody; ELF1 antibody; ELF1_HUMAN antibody; Ets domain transcription factor antibody; ETS related transcription factor Elf 1 antibody; ETS related transcription factor Elf1 antibody; ets-related transcription factor antibody; ETS-related transcription factor Elf-1 antibody; mElf 1 antibody; p70 antibody; Sts1 antibody; TRANSCRIPTION FACTOR ELF 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Elf-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
  • 基因功能参考文献：
    1. ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region. PMID: 26553150
    2. ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation. PMID: 26643049
    3. Data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients. PMID: 21811762
    4. Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells. PMID: 21931859
    5. The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density. PMID: 20346215
    6. the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells. PMID: 21867680
    7. through a genome-wide association in a Hong Kong Chinese cohort and replication in 2 other Asian populations, identified association of ELF1 with systemic lupus erythematosus PMID: 21044949
    8. The expression levels of both Elf-1 and VEGF were significantly related with tumor differentiation, lymphatic metastasis, clinical stage, and postoperative survival time in non-small cell lung cancer. PMID: 19624906
    9. ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression PMID: 20600580
    10. transcriptional regulation of the LAT gene, including the discovery that the Ets transcription factor Elf-1 may play a central role in its expression PMID: 16464244
    11. These results provide new evidence that Elf-1 is involved in transcriptional activation of hPygo2. PMID: 18314487
    12. Elf-1 in combination with Sp1 and GABP reduced FcRgamma promoter activity. PMID: 18378679
    13. aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231, resulting in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters. PMID: 18714041
    14. Includes a comparison of MEF to ELF1. PMID: 10207087

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, l
  • 数据库链接：

    HGNC: 3316

    OMIM: 189973

    KEGG: hsa:1997

    STRING: 9606.ENSP00000239882

    UniGene: Hs.135646