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ELF4 Antibody

  • 货号：
    CSB-PA857453ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA857453ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA857453ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA857453ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELF4 Polyclonal antibody
  • Uniprot No.：
    Q99607
  • 基因名：
    ELF4
  • 别名：
    E74-like factor 4 antibody; ELF4 antibody; ELF4_HUMAN antibody; ELFR antibody; ETS-related transcription factor Elf-4 antibody; ETS-related transcription factor Elf4 antibody; MEF antibody; Myeloid Elf-1-like factor antibody; Myeloid Elf1-like factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ETS-related transcription factor Elf-4 protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
  • 基因功能参考文献：
    1. Overall, these data indicate that hypoxia or HIF-1alpha positively regulates MEF expression and function. PMID: 27040637
    2. The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells PMID: 25482012
    3. The p53-MDM2-MEF axis is a feedback mechanism that exquisitely controls the balance of these transcriptional regulators. PMID: 25081543
    4. These studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. PMID: 23217424
    5. enhanced HDM2 expression induced by mutant NPM1 may have a role in MEF/ELF4-dependent leukemogenesis PMID: 23393136
    6. MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression. PMID: 21465527
    7. Loss of ELF4 leads to increased quiescence in bone marrow endothelial cells by the deregulation of cyclin-dependent kinase-4 expression and to enhanced regeneration of sinusoidal blood vessels. PMID: 21350194
    8. Functional dissection of the transactivation mechanisms of the ETS transcription factor MEF PMID: 12151102
    9. MEF is an important regulator of IL-8 expression PMID: 14625302
    10. promyelocytic leukemia protein, but not Sp100, induced the accumulation of MEF in PML nuclear bodies and MEF and PML physically interacted, stimulating MEF transcriptional activity, resulting in the up-regulation of endogenous lysozyme expression. PMID: 14976184
    11. regulation in epithelial cells by Sp1 PMID: 15907486
    12. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. PMID: 16303180

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  • 相关疾病：
    A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.
  • 亚细胞定位：
    Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cel
  • 数据库链接：

    HGNC: 3319

    OMIM: 300775

    KEGG: hsa:2000

    STRING: 9606.ENSP00000311280

    UniGene: Hs.271940