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ELK3 Antibody

  • 货号：
    CSB-PA007606LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA007606LA01HU diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA007606LA01HU diluted at 1:500 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELK3 Polyclonal antibody
  • Uniprot No.：
    P41970
  • 基因名：
  • 别名：
    ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ETS domain-containing protein Elk-3 protein (163-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ELK3 Antibody (CSB-PA007606LA01HU)，的标记方式是Non-conjugated。对于ELK3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA007606LB01HU ELK3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007606LC01HU ELK3 Antibody, FITC conjugated
    Biotin CSB-PA007606LD01HU ELK3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
  • 基因功能参考文献：
    1. Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
    2. Net might play an important role in pancreatic carcinogenesis PMID: 23469073
    3. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
    4. The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
    5. We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
    6. Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
    7. High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
    8. results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
    9. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
    10. ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
    11. Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
    12. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
    13. These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    HGNC: 3325

    OMIM: 600247

    KEGG: hsa:2004

    STRING: 9606.ENSP00000228741

    UniGene: Hs.46523