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  4. ELL2 Antibody

ELL2 Antibody

  • 货号：
    CSB-PA008287
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O00472
  • 基因名：
    ELL2
  • 别名：
    ELL related RNA polymerase II elongation factor antibody; Ell2 antibody; ELL2_HUMAN antibody; Elongation factor for RNA polymerase II 2 antibody; Elongation factor RNA for polymerase II 2 antibody; Elongation factor RNA polymerase II 2 antibody; RNA polymerase II elongation factor ELL2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ELL2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
  • 基因功能参考文献：
    1. Study in CD138+ plasma cells from 1630 multiple myeloma (MM) patients show that the MM risk allele at 5q15 lowers ELL2 expression in these cells, but not in peripheral blood or other tissues. PMID: 29695719
    2. Study reports the 2.0-A resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding site on AFF4, the ELLBow. The ELLBow consists of an N-terminal helix followed by an extended hairpin and occupies most of the concave surface of ELL2. This surface is important for the ability of ELL2 to promote HIV-1 Tat-mediated proviral transcription. PMID: 28134250
    3. Knockdown of RNA polymerase II elongation factor ELL2 (ELL2) sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage. PMID: 29179998
    4. expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating multiple myeloma clonal expansion. PMID: 28903037
    5. Results provide the first evidence that ELL2 is a direct target of miR-299 and increased ELL2 expression and down-regulation of miR-299 are associated with GBM progression and poor prognosis in patients. PMID: 28531325
    6. Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival PMID: 28858629
    7. These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer. PMID: 28870994
    8. multiple myeloma risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation PMID: 26007630
    9. Tax transactivates the ELL2 promoter in HTLV-1-infected T-cells. PMID: 25058508
    10. Loss of ELL2 in B cells results in decreased Igh secretory mRNA and decreased expression of Ig light chain plus genes involved in the unfolded protein response like XBP1, ATF6, BiP, cyclin B2, OcaB (BOB1, Pou2af1). PMID: 25238757
    11. Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 expression and ELL2 polyubiquitination. PMID: 22483617
    12. ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping PMID: 19749764

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ELL/occludin family
  • 数据库链接：

    HGNC: 17064

    OMIM: 601874

    KEGG: hsa:22936

    STRING: 9606.ENSP00000237853

    UniGene: Hs.192221