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ELOVL2 Antibody

  • 货号：
    CSB-PA030151
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NXB9
  • 基因名：
    ELOVL2
  • 别名：
    ELOVL2; ELG3; SSC2; Elongation of very long chain fatty acids protein 2; 3-keto acyl-CoA synthase ELOVL2; ELOVL fatty acid elongase 2; ELOVL FA elongase 2; Very long chain 3-ketoacyl-CoA synthase 2; Very long chain 3-oxoacyl-CoA synthase 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ELOVL2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
  • 基因功能参考文献：
    1. Results shows that ELOVL2 promoter displays an exceptionally consistent increase in DNA methylation with age in all tissues. PMID: 29848354
    2. ELOVL2 methylation is a marker of cell divisions occurring during human aging PMID: 27672102
    3. common variations not associated with polyunsaturated fatty acid levels in breast milk PMID: 28245901
    4. Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERalpha in Breast Cancer Cells PMID: 27788154
    5. Polymorphisms in the ELOVL2 gene were not associated with the risk of developing allergic disease PMID: 26633493
    6. results show that the ELOVL2 locus provides a very good source of information about human chronological age based on analysis of blood, including bloodstains, and it may constitute a powerful and reliable predictor in future forensic age estimation models PMID: 25450787
    7. we do not found the association between rs3756593 of ELOVL2 gene and acute coronary syndrome in Chinese Han population PMID: 23555103
    8. Methylation of ELOVL2 gene is a new epigenetic marker of age. PMID: 23061750
    9. rs3756963 in ELOVL2 gene may be associated with paranoid schizophrenia. PMID: 21560298
    10. gene interaction analysis showed that the combined genotype of FADS1 rs174556 (T/T) and ELOVL2 rs3756963 (T/T) was weakly associated with coronary artery disease PMID: 21917437

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ELO family, ELOVL2 subfamily
  • 组织特异性：
    Liver and testis.
  • 数据库链接：

    HGNC: 14416

    OMIM: 611814

    KEGG: hsa:54898

    STRING: 9606.ENSP00000346693

    UniGene: Hs.656436