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ELOVL5 Antibody

  • 货号：
    CSB-PA882144LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA882144LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELOVL5 Polyclonal antibody
  • Uniprot No.：
    Q9NYP7
  • 基因名：
    ELOVL5
  • 别名：
    ELOVL5; ELOVL2; PRO0530; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Elongation of very long chain fatty acids protein 5 protein (247-299AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ELOVL5 Antibody (CSB-PA882144LA01HU)，的标记方式是Non-conjugated。对于ELOVL5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882144LB01HU ELOVL5 Antibody, HRP conjugated ELISA
    FITC CSB-PA882144LC01HU ELOVL5 Antibody, FITC conjugated
    Biotin CSB-PA882144LD01HU ELOVL5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.
  • 基因功能参考文献：
    1. Low ELOVL5 expression is associated with colorectal cancer. PMID: 28931069
    2. common variations associated with polyunsaturated fatty acid levels in breast milk PMID: 28245901
    3. SCA38 subtype is very rare in Mainland China; no disease-related gene mutations in ELOVL5. PMID: 26433464
    4. performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1 PMID: 26321664
    5. In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum. PMID: 25065913
    6. Changes in the mRNA-expression levels of FADS1 and 2 directly affect blood DGLA levels and D6D activity. This study suggests that lower mRNA-expressions of FADS2 and ELOVL5 are associated with higher risk of atopic eczema in young children. PMID: 24167612
    7. a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2-Akt-FoxO1 pathway PMID: 23099444
    8. minor allele copies at rs2294867 associated with an increase in total and LDL cholesterol...number of minor allele copies at rs761179 associated with increase in total cholesterol... However, associations not replicated in independent populations. PMID: 22293571
    9. Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset. PMID: 21508110
    10. Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. PMID: 21383846

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  • 相关疾病：
    Spinocerebellar ataxia 38 (SCA38)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    ELO family, ELOVL5 subfamily
  • 组织特异性：
    Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.
  • 数据库链接：

    HGNC: 21308

    OMIM: 611805

    KEGG: hsa:60481

    UniGene: Hs.520189