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  4. ELP4 Antibody

ELP4 Antibody

  • 货号：
    CSB-PA007628GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96EB1
  • 基因名：
    ELP4
  • 别名：
    C11orf19 antibody; dJ68P15A.1 antibody; elongation protein 4 homolog (S. cerevisiae) antibody; Elongation protein 4 homolog antibody; Elongator complex protein 4 antibody; ELP4 antibody; ELP4_HUMAN antibody; FLJ20498 antibody; hELP4 antibody; PAX6 neighbor gene protein antibody; PAX6NEB antibody; PAXNEB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ELP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
  • 基因功能参考文献：
    1. Our results suggest that ELP4 deletions are highly likely to be pathogenic, predisposing to a range of neurodevelopmental phenotypes from ASD to language impairment and epilepsy. PMID: 26010655
    2. Results show no difference in BDNF and ELP4 genotype frequencies between benign epilepsy with centrotemporal spikes patients and controls; haplotype analysis also revealed no statistical difference PMID: 25301525
    3. No association of SNPs in the ELP4 gene was detected in rolandic epilepsy patients. PMID: 24995671
    4. Data suggest that a non-coding mutation in ELP4 impairs brain-specific Elongator-mediated interaction of genes implicated in brain development, resulting in susceptibility to seizures and neurodevelopmental disorders. PMID: 19172991
  • 相关疾病：
    Aniridia 2 (AN2)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ELP4 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 1171

    OMIM: 606985

    KEGG: hsa:26610

    STRING: 9606.ENSP00000298937

    UniGene: Hs.175534