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EMC1 Antibody

  • 货号：
    CSB-PA208661
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA208661(EMC1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 15 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q8N766
  • 基因名：
  • 别名：
    2700016F22Rik antibody; C230096C10Rik antibody; Emc1 antibody; ER membrane protein complex subunit 1 antibody; Hypothetical protein LOC23065 antibody; K0090_HUMAN antibody; KIAA0090 antibody; mKIAA0090 antibody; OTTHUMP00000215527 antibody; PSEC0263 antibody; RIKEN cDNA C230096C10 gene antibody; RP1-43E13.1 antibody; RP23-371E13.1 antibody; Uncharacterized protein KIAA0090 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human EMC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
  • 基因功能参考文献：
    1. The s find that a member of the endoplasmic reticulum membrane protein complex (EMC) called EMC1 promotes SV40 virus endoplasmic reticulum membrane transport and infection. PMID: 28012275
    2. EMC1 is a gene in which either biallelic or monoallelic variants might lead to a syndrome including intellectual disability and preferential degeneration of the cerebellum. PMID: 26942288
  • 相关疾病：
    Cerebellar atrophy, visual impairment, and psychomotor retardation (CAVIPMR)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    EMC1 family
  • 数据库链接：

    HGNC: 28957

    OMIM: 616846

    KEGG: hsa:23065

    STRING: 9606.ENSP00000420608

    UniGene: Hs.439200