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EMC8 Antibody

  • 货号：
    CSB-PA005835LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA005835LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western blot
      All lanes: EMC8 antibody at 4µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Human placenta tissue
      Lane 3: Hela whole cell lysate
      Lane 4: HT29 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 24, 14 kDa
      Observed band size: 24 kDa
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA005835LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA005835LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EMC8 Polyclonal antibody
  • Uniprot No.：
    O43402
  • 基因名：
    EMC8
  • 别名：
    C16orf2 antibody; C16orf4 antibody; COX4 neighbor antibody; COX4; neighbor of antibody; COX4AL antibody; Cox4nb antibody; CX4NB_HUMAN antibody; ER membrane protein complex subunit 8 antibody; FAM158B antibody; family with sequence similarity 158; member B antibody; Neighbor of COX4 antibody; NOC4 antibody; Protein FAM158B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ER membrane protein complex subunit 8 protein (1-210AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EMC8 Antibody (CSB-PA005835LA01HU)，的标记方式是Non-conjugated。对于EMC8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA005835LB01HU EMC8 Antibody, HRP conjugated ELISA
    FITC CSB-PA005835LC01HU EMC8 Antibody, FITC conjugated
    Biotin CSB-PA005835LD01HU EMC8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    EMC8/EMC9 family
  • 组织特异性：
    Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.
  • 数据库链接：

    HGNC: 7864

    OMIM: 604886

    KEGG: hsa:10328

    STRING: 9606.ENSP00000253457

    UniGene: Hs.173162