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EMCN Antibody

  • 货号：
    CSB-PA007632ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA007632ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007632ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    Rabbits were immunized with the recombinant human Endomucin protein (19-135aa) to produce the EMCN polyclonal antibodies. This stimulates the rabbit's immune system to produce a varied set of antibodies that recognize distinct epitopes on the antigen. Subsequently, the antibodies were purified from the rabbits' sera using antigen affinity chromatography.

    The effectiveness of the EMCN antibody was evaluated in ELISA and IHC applications, and it was found to efficiently identify and bind the EMCN protein in human samples. The EMCN protein is involved in controlling vascular permeability and angiogenesis, which is the process of forming new blood vessels.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EMCN Polyclonal antibody
  • Uniprot No.：
    Q9ULC0
  • 基因名：
    EMCN
  • 别名：
    EMCN antibody; EMCN2 antibody; Endomucin 2 antibody; Endomucin antibody; Endomucin-2 antibody; Endothelial sialomucin antibody; Gastric cancer antigen Ga34 antibody; MUC-14 antibody; MUC14 antibody; MUCEN_HUMAN antibody; Mucin 14 antibody; Mucin-14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Endomucin protein (19-135AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
  • 基因功能参考文献：
    1. In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 regulates entrance of lymphocytes from the SS to the lymph node parenchyma PMID: 27601677
    2. These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues. PMID: 26831939
    3. Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation. PMID: 21666600
    4. A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis. PMID: 21159824
  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.; [Isoform 2]: Secreted.
  • 组织特异性：
    Expressed in heart, kidney and lung.
  • 数据库链接：

    HGNC: 16041

    OMIM: 608350

    KEGG: hsa:51705

    STRING: 9606.ENSP00000296420

    UniGene: Hs.152913