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  4. ENC1 Antibody

ENC1 Antibody

  • 货号：
    CSB-PA007663GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14682
  • 基因名：
    ENC1
  • 别名：
    CCL 28 antibody; CCL28 antibody; Ectoderm neural cortex protein 1 antibody; Ectoderm-neural cortex protein 1 antibody; Ectodermal neural cortex (with BTB like domain) antibody; ENC 1 antibody; ENC-1 antibody; ENC1 antibody; ENC1_HUMAN antibody; FLJ39259 antibody; Kelch like 35 antibody; Kelch like 37 antibody; Kelch-like protein 37 antibody; KLHL 35 antibody; KLHL35 antibody; KLHL37 antibody; NRPB antibody; Nuclear matrix protein NRP/B antibody; Nuclear restricted protein BTB domain like (brain) antibody; OTTHUMP00000128235 antibody; OTTHUMP00000222054 antibody; p53 induced gene 10 protein antibody; p53-induced gene 10 protein antibody; PIG 10 antibody; PIG10 antibody; TP53I10 antibody; Tumor protein p53 inducible protein 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ENC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
  • 基因功能参考文献：
    1. ENC1 interacts with the phosphorylated p62 to impair autophagic degradation of mutant huntingtin protein aggregates. PMID: 26637326
    2. we identified ENC1 and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evidence supporting a potential role in the dissociation of cognition and neuropathology in an aging population. PMID: 28441426
    3. results suggest that upregulation of ENC-1 contributes to the development of HCL and provides new information on the possible dysregulation of ENC-1 including expression of a novel antisense gene, ENC-1AS PMID: 15459180
    4. NRP/B enhances oxidative stress responses in breast cancer cells via the Nrf2 pathway, identifying a novel role of nuclear matrix protein(s) in oxidative stress responses. PMID: 17875699
    5. NRP/B mutations impair Nrf2-dependent NQO1 induction in primary brain tumors. PMID: 18981988
    6. ENC1 functions as a negative regulator of Nrf2 through suppressing Nrf2 protein translation. PMID: 19424503

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  • 亚细胞定位：
    Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma
  • 数据库链接：

    HGNC: 3345

    OMIM: 605173

    KEGG: hsa:8507

    STRING: 9606.ENSP00000306356

    UniGene: Hs.104925