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EPHA10 Antibody

  • 货号：
    CSB-PA683366LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of NIH/3T3 cells with CSB-PA683366LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EPHA10 Polyclonal antibody
  • Uniprot No.：
    Q5JZY3
  • 基因名：
    EPHA10
  • 别名：
    Ephrin type-A receptor 10 (EC 2.7.10.1), EPHA10
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ephrin type-A receptor 10 protein (242-564aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，EPHA10 Antibody (CSB-PA683366LA01HU)，的标记方式是Non-conjugated。对于EPHA10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA683366LB01HU EPHA10 Antibody, HRP conjugated ELISA
    FITC CSB-PA683366LC01HU EPHA10 Antibody, FITC conjugated
    Biotin CSB-PA683366LD01HU EPHA10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
  • 基因功能参考文献：
    1. we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage. PMID: 28427223
    2. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
    3. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers PMID: 24946238
    4. Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here. PMID: 24924629
    5. EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression. PMID: 24403271
    6. EPHA10 does not interact with EPHB6 in breast neoplasms PMID: 21737611
    7. CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10. PMID: 18819711

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Mainly expressed in testis.
  • 数据库链接：

    HGNC: 19987

    OMIM: 611123

    KEGG: hsa:284656

    STRING: 9606.ENSP00000362139

    UniGene: Hs.129435