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EPHA6 Antibody

  • 货号：
    CSB-PA008926
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UF33
  • 基因名：
    EPHA6
  • 别名：
    Ehk 2 antibody; EHK-2 antibody; Ehk2 antibody; EPH homology kinase 2 antibody; Eph Receptor A6 antibody; Epha6 antibody; EPHA6_HUMAN antibody; ephrin receptor EphA6 antibody; ephrin type A receptor 6 antibody; Ephrin type-A receptor 6 antibody; Hek12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human EphA6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
  • 基因功能参考文献：
    1. The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population. PMID: 29208002
    2. Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy PMID: 27582484
    3. EphA6 mRNA expression is higher in 112 CaP tumor samples compared with benign tissues from 58 benign prostate hyperplasia patients. Positive correlation was identified between EphA6 expression and vascular invasion, neural invasion, PSA level, and TNM staging in CaP cases. PMID: 26041887
    4. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. PMID: 25583493
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    7. During development of the retinal vasculature, migration of ligand-bearing astrocytes is slowed along Eph-A6 expression gradient through repellent Eph-A6 - ephrin-A1 and -A4 signaling. PMID: 20011078
    8. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Expressed in brain and testis.
  • 数据库链接：

    HGNC: 19296

    OMIM: 600066

    KEGG: hsa:285220

    STRING: 9606.ENSP00000374323

    UniGene: Hs.272208