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EPHA7 Antibody

  • 货号：
    CSB-PA008064
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293T-UV cells using EphA7 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15375
  • 基因名：
  • 别名：
    Cek 11 antibody; Developmental kinase 1 antibody; EBK antibody; EHK-3 antibody; EHK3 antibody; EK11 antibody; Embryonic brain kinase antibody; EPH homology kinase 3 antibody; EPH-like kinase 11 antibody; Epha7 antibody; EPHA7_HUMAN antibody; Ephrin receptor Eph A7 antibody; Ephrin type A receptor 7 antibody; Ephrin type-A receptor 7 antibody; hEK11 antibody; MDK 1 antibody; Receptor protein tyrosine kinase HEK 11 antibody; Tyrosine protein kinase receptor EHK 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human EphA7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
  • 基因功能参考文献：
    1. receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways. PMID: 29022918
    2. these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7. PMID: 28604772
    3. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness. PMID: 27566654
    4. Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway. PMID: 26936314
    5. Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells. PMID: 25968442
    6. s observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not. PMID: 25855521
    7. miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs. PMID: 24927112
    8. MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma. PMID: 21964981
    9. The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma. PMID: 21609571
    10. Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue. PMID: 22246354
    11. EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas. PMID: 22036564
    12. EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma. PMID: 20302756
    13. analysis of the secreted form of EphA7 in lung cancer PMID: 20126984
    14. downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis PMID: 16007213
    15. EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033) PMID: 17669470
    16. siRNA-mediated suppression of ALL1/AF4 in SEMK2 cells carrying the t(4;11) chromosome translocation resulted in down-regulation of EphA7 PMID: 17726105
    17. EphA7 protein may have a role in progression of glioblastoma multiforme PMID: 18366728
    18. epigenetic inactivation of EphA7 may be involved in prostate carcinogenesis PMID: 18821581

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 3390

    OMIM: 602190

    KEGG: hsa:2045

    STRING: 9606.ENSP00000358309

    UniGene: Hs.73962