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EPN1 Antibody

  • 货号：
    CSB-PA002387
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MOuse-brain cells using Epsin 1 Polyclonal Antibody
    • Western Blot analysis of K562 cells using Epsin 1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6I3
  • 基因名：
  • 别名：
    EH domain binding mitotic phosphoprotein antibody; EH domain-binding mitotic phosphoprotein antibody; EPN 1 antibody; Epn1 antibody; EPN1_HUMAN antibody; EPS 15 interacting protein 1 antibody; EPS-15-interacting protein 1 antibody; Epsin 1 antibody; Epsin-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Epsin 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis.
  • 基因功能参考文献：
    1. Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2). PMID: 29362354
    2. Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1. PMID: 26975582
    3. intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
    4. AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals PMID: 21965661
    5. An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations PMID: 12353027
    6. Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin. PMID: 15694383
    7. epsin 1 promotes endocytosis of the ubiquitinated EGF receptor PMID: 19054389
    8. Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells. PMID: 19704019

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit.
  • 蛋白家族：
    Epsin family
  • 数据库链接：

    HGNC: 21604

    OMIM: 607262

    KEGG: hsa:29924

    UniGene: Hs.279953