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  4. ERAS Antibody

ERAS Antibody

  • 货号：
    CSB-PA009263
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z444
  • 基因名：
    ERAS
  • 别名：
    E ras antibody; E-Ras antibody; ecat5 antibody; Embryonic stem cell expressed Ras antibody; Embryonic stem cell-expressed Ras antibody; Eras antibody; ES cell expressed Ras antibody; GTPase ERas antibody; Ha-Ras2 antibody; HRAS2 antibody; HRASP antibody; MGC126691 antibody; MGC126693 antibody; OTTHUMP00000065857 antibody; RASE_HUMAN antibody; Small GTPase protein E Ras antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human E-Ras.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.
  • 基因功能参考文献：
    1. N-terminal extension of E-RAS is important for E-RAS signaling activity. PMID: 25940089
    2. Expression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphosphorylation of AKT. PMID: 25624498
    3. After knocking down the ERas gene by siRNA, we observed that there was a significant decrease in proliferation, metastasis as well as clonality in gastric carcinoma. PMID: 23612786
    4. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
    5. ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted. PMID: 21151392
    6. These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin. PMID: 20566745
    7. ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma. PMID: 20811723
    8. transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells PMID: 12774123
    9. Studies on ERas gene expression. PMID: 16081664
    10. rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms PMID: 18174262
    11. High ERas is associated with the tumorigenic process of gastric carcinomas. PMID: 19528480
    12. Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer. PMID: 19787253

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    HGNC: 5174

    OMIM: 300437

    KEGG: hsa:3266

    STRING: 9606.ENSP00000339136

    UniGene: Hs.447330