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ERN2 Antibody

  • 货号：
    CSB-PA436972
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA436972(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436972(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q76MJ5
  • 基因名：
    ERN2
  • 别名：
    ERN2 antibody; IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody; Endoplasmic reticulum-to-nucleus signaling 2 antibody; Inositol-requiring protein 2 antibody; hIRE2p antibody; Ire1-beta antibody; IRE1b) [Includes: Serine/threonine-protein kinase antibody; EC 2.7.11.1); Endoribonuclease antibody; EC 3.1.26.-)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ERN2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
  • 基因功能参考文献：
    1. ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review) PMID: 27774654
    2. The luminal event mediated by IRE1beta involves direct interaction with unfolded proteins rather than association/dissociation with BiP. PMID: 23236464
    3. Data show that IRE1beta represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1beta. PMID: 21146530
    4. The structural, biochemical, and functional studies in vivo altogether demonstrate that IRE1 and PERK have conserved a common molecular interface necessary and sufficient for dimerization and unfolded protein response (UPR) signaling. PMID: 16973740
    5. RNase domain of IRE1 determines the functional specificities of each of these isoforms. PMID: 18242182

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 数据库链接：

    HGNC: 16942

    OMIM: 604034

    KEGG: hsa:10595

    STRING: 9606.ENSP00000256797

    UniGene: Hs.592041