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ERO1LB Antibody

  • 货号：
    CSB-PA007798GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86YB8
  • 基因名：
  • 别名：
    Endoplasmic oxidoreductin-1-like protein B antibody; Endoplasmic reticulum oxidoreductin-1-like protein B antibody; ERO1; S. cerevisiae; homolog of; beta antibody; ERO1-L-beta antibody; ERO1-like beta (S. cerevisiae) antibody; ERO1-like protein beta antibody; ERO1B_HUMAN antibody; Ero1lb antibody; Oxidoreductin-1-L-beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human ERO1LB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
  • 基因功能参考文献：
    1. This peptide, Ac-VDTTD-AFC, was efficiently cleaved by purified caspase-2 and auto-activating caspase-2 in mammalian cells, and exhibited better selectivity for caspase-2 relative to caspase-3 than reagents that are currently available. PMID: 27919037
    2. GJB2 and ERO1LB are implicated in pancreatic cancer progression and can be used to predict patient survival PMID: 28177904
    3. upregulated in pancreatic neuroendocrine tumors PMID: 26765469
    4. In the present work, it was shown that recombinant human Ero1beta is twice as active as Ero1alpha in enzymatic assays. PMID: 21091435
    5. glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum PMID: 15161913
    6. analysis of Ero1beta tissue distribution and dimerization PMID: 16012172
    7. Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 PMID: 16677073
    8. the Ero FAD binding domain is critical for conformational stability, allowing Ero proteins to withstand stress conditions that cause client proteins to misfold PMID: 16822866
    9. The lack of correlation between changes in SAT adiponectin gene and protein expression and its circulating levels suggests that adipose tissue synthesis and release of adiponectin are highly regulated pathways. PMID: 18996753

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
  • 蛋白家族：
    EROs family
  • 组织特异性：
    Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enz
  • 数据库链接：

    HGNC: 14355

    OMIM: 615437

    KEGG: hsa:56605

    STRING: 9606.ENSP00000346635

    UniGene: Hs.558519