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ERVFRD-1 Antibody

  • 货号：
    CSB-PA352689LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate,SH-SY5Y whole cell lysate,HT-29 whole cell lysate,293T whole cell lysate,K562 whole cell lysate,Mouse liver tissue
      All lanes: ERVFRD-1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ERVFRD-1 Polyclonal antibody
  • Uniprot No.：
    P60508
  • 基因名：
    ERVFRD-1
  • 别名：
    Syncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU), Transmembrane protein (TM)], ERVFRD-1, ERVFRDE1
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Syncytin-2 protein (33-315aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ERVFRD-1 Antibody (CSB-PA352689LA01HU)，的标记方式是Non-conjugated。对于ERVFRD-1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA352689LB01HU ERVFRD-1 Antibody, HRP conjugated ELISA
    FITC CSB-PA352689LC01HU ERVFRD-1 Antibody, FITC conjugated
    Biotin CSB-PA352689LD01HU ERVFRD-1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process.; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein m...显示更多
  • 基因功能参考文献：
    1. genetic predisposition in ERVFRDE-1 may be associated with an increased risk of preeclampsia. This polymorphism is possibly involved in the regulation of syncytin-2 expression in preeclamptic placenta. PMID: 29750965
    2. N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2. PMID: 26853155
    3. Decreased syncytin-2 and MFSD2 proteins in gestational diabetic placentas might cause abnormal syncytiotrophoblast formation and possibly be involved in the pathology PMID: 26875564
    4. ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia. PMID: 26992684
    5. These results thereby demonstrate that induced expression of Syncytin-2 is highly dependent on the interaction of bZIP-containing transcription factors to a CRE/AP-1 motif and that this element is important for the regulation of Syncytin-2 expression PMID: 25781974
    6. MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion. PMID: 23177091
    7. results further highlighted the existence of a correlation between the extent of the decrease in the expression levels of both syncytins 1 and 2 fusogenic proteins and the degree of severity of preeclampsia symptoms PMID: 21493955
    8. Analysis of non-spliced ERVFRDE1 mRNAs and env mRNAs detected efficient splicing of endogenously expressed RNAs in trophoblastic but not in non-placental cells. PMID: 21771862
    9. The crystal structure of a central fragment of syncytin 2 "fossil" ectodomain is reported, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses PMID: 16140326
    10. immunolocalized only in the villous trophoblast of the chorionic villi, at the level of cytotrophoblastic cells PMID: 16714059
    11. findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not PMID: 18077339
    12. Syncytin 2 expression illustrates the abnormal trophoblast differentiation observed in placenta of fetal T21-affected pregnancies. PMID: 18215254
    13. expression decreased in preeclamptic placentas; may function as a second fusogenic protein for placental cell fusion PMID: 18650494
    14. These results highlight the importance of Syncytin-2 in BeWo and primary human trophoblast cell fusion. PMID: 19616006

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  • 亚细胞定位：
    Virion.; [Surface protein]: Cell membrane; Peripheral membrane protein.; [Transmembrane protein]: Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    Gamma type-C retroviral envelope protein family, HERV class-I FRD env subfamily
  • 组织特异性：
    Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • 数据库链接：

    HGNC: 33823

    OMIM: 610524

    KEGG: hsa:405754

    STRING: 9606.ENSP00000420174

    UniGene: Hs.631996