Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. EXOC4 Antibody

EXOC4 Antibody

  • 货号：
    CSB-PA007882GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96A65
  • 基因名：
    EXOC4
  • 别名：
    dSec8 antibody; EXOC 4 antibody; Exoc4 antibody; EXOC4_HUMAN antibody; Exocyst complex component 4 antibody; Exocyst complex component SEC8 antibody; KIAA1699 antibody; MGC27170 antibody; REC 8 antibody; REC8 antibody; rSec 8 antibody; Sec 8 antibody; Sec 8p antibody; Sec8 antibody; SEC8 like 1 antibody; SEC8 protein antibody; Sec8L1 antibody; Sec8p antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EXOC4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
  • 基因功能参考文献：
    1. Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the epithelial-mesenchymal transition. PMID: 27769780
    2. Sec8 regulate Bcl-2 and Mcl-1 expressions but not Bcl-xl in malignant peripheral nerve sheath tumor cells. PMID: 26892009
    3. Sec8 regulates histone-modifying proteins ATF2 and RNF20. PMID: 26283729
    4. Sec8 knockdown in HSC3 cells resulted in reduced expressions of PAK1 and PAK2 by upregulating Pirh2 and Siah1 expression, which inhibited the ERK or p38 MAPK signalling pathway and cytokeratin8 phosphorylation and cell migration. PMID: 25725287
    5. knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38. PMID: 25244576
    6. Exome sequencing revealed a likely pathogenic mutation in three novel candidate MKS disease genes-C5orf42, EVC2 and SEC8 (also known as EXOC4), which encodes an exocyst protein with an established role in ciliogenesis PMID: 23169490
    7. High Sec8 expression is associated with progression of oral squamous-cell carcinoma by secretion of matrix metalloproteinases. PMID: 23207790
    8. EXOC4 is involved in insulin-stimulated glucose transport and may be a candidate for an association with type 2 diabetes. PMID: 18498660

    显示更多

    收起更多

  • 亚细胞定位：
    Midbody, Midbody ring. Cell projection.
  • 蛋白家族：
    SEC8 family
  • 数据库链接：

    HGNC: 30389

    OMIM: 608185

    KEGG: hsa:60412

    STRING: 9606.ENSP00000253861

    UniGene: Hs.321273